Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults.
Breno S DinizErica M VieiraAna Paula Mendes-SilvaChristopher R BowieMeryl A ButtersCorinne E FischerAlastair FlintNathan HerrmannJames KennedyKrista L LanctôtLinda MahBruce G PollockBenoit H MulsantTarek K Rajjinull nullPublished in: Alzheimer's & dementia (New York, N. Y.) (2021)
Our study suggests that increased molecular changes are associated with cognitive impairment in older adults with MDD and indicate that accelerated biological aging is an underlying feature of MDD.