A randomised phase II study of extended pleurectomy/decortication preceded or followed by chemotherapy in patients with early-stage pleural mesothelioma: EORTC 1205.
Jo RaskinVeerle SurmontAlexander P W M MaatMaha YahiaSjaak A BurgersYassin PretzenbacherFrederic De RyckRobin CornelissenHouke M KlompAna OliveiraJoachim AertsPaul BaasSandrine MarreaudJan P Van MeerbeeckPaul E Y Van SchilPublished in: The European respiratory journal (2024)
EORTC 1205 did not succeed in selecting a preferred sequence of pre- or post-operative chemotherapy. Either procedure is feasible with a low mortality, albeit consistent morbidity. A shared informed decision between surgeon and patient remains essential.
Keyphrases
- phase ii study
- locally advanced
- open label
- early stage
- rectal cancer
- neoadjuvant chemotherapy
- squamous cell carcinoma
- placebo controlled
- clinical trial
- radiation therapy
- case report
- double blind
- cardiovascular events
- minimally invasive
- study protocol
- sentinel lymph node
- decision making
- robot assisted
- chemotherapy induced
- risk factors
- type diabetes
- cardiovascular disease
- coronary artery disease
- amino acid
- lymph node