ATP mediates a negative autocrine signal on stimulus-secretion coupling in mouse pancreatic β-cells.

Cita BauerJulia KaiserJelena SikimicPeter Krippeit-DrewsMartina Düfer Gisela Drews

Published in: Endocrine (2018)

It is suggested that extracellular ATP which is co-secreted with insulin in a pulsatile manner during glucose-stimulated exocytosis provides a negative feedback signal driving β-cell oscillations in co-operation with Ca2+ and other signals.

Keyphrases

induced apoptosis
type diabetes
cell cycle arrest
single cell
cell therapy
working memory
blood glucose
glycemic control
room temperature
endoplasmic reticulum stress
stem cells
cell death
blood pressure
adipose tissue
mesenchymal stem cells
skeletal muscle