Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals.
Yuqing ChenIrfahan KassamSuk Hiang LauJaspal S KoonerRory WilsonAnnette PetersJuliane WinkelmannJohn C ChambersVincent T ChowChiea Chuen KhorRob M van DamYik-Ying TeoMarie LohXueling S SimPublished in: Clinical epigenetics (2021)
Our study provides evidence of an association between obesity and DNA methylation in multi-ethnic Asians and suggests that obesity can drive methylation change. The results also suggested possible causal influence that obesity-related methylation changes might have on inflammation and lipoprotein levels.