Leptin and insulin up-regulate miR-4443 to suppress NCOA1 and TRAF4, and decrease the invasiveness of human colon cancer cells.

Published in: BMC cancer (2016)

Our findings suggest that miR-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 and NCOA1 downstream of MEK-C/EBP-mediated leptin and insulin signaling, and that insulin and/or leptin resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC.

Keyphrases

type diabetes
cell proliferation
long non coding rna
glycemic control
long noncoding rna
endothelial cells
insulin resistance
metabolic syndrome
squamous cell carcinoma
small cell lung cancer
induced pluripotent stem cells
adipose tissue
skeletal muscle
signaling pathway