Autoantibodies against the melanoma differentiation-associated protein 5 in patients with dermatomyositis target the helicase domains.
Eveline Van GompelDeniz DemirdalCatia Fernandes-CerqueiraBegum HoruluogluAngeles Galindo-FeriaEdvard WigrenSusanne GräslundEllen De LangheOlivier BenvenisteAntonella NotarnicolaKarine CheminIngrid E LundbergPublished in: Rheumatology (Oxford, England) (2023)
Our data revealed that the main immunogenic targets of anti-MDA5 autoantibodies from MDA5(+) patients are the helicase domains. Considering that the helicase domains are responsible for the enzymatic activity and subsequent triggering of an inflammatory response, our findings suggest that binding of anti-MDA5 autoantibodies could alter the canonical activity of the MDA5 protein and potentially affect the downstream induction of a pro-inflammatory cascade.
Keyphrases
- breast cancer cells
- systemic lupus erythematosus
- inflammatory response
- end stage renal disease
- cell cycle arrest
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- disease activity
- electronic health record
- lipopolysaccharide induced
- transcription factor
- immune response
- cell death
- big data
- rheumatoid arthritis
- nitric oxide
- small molecule
- deep learning
- pi k akt