Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease.

Leon C D SmythHelen C MurrayMadison HillEve van LeeuwenBlake HighetNicholas J MagonMahyar OsanlouySophie N MathiesenBruce MockettMalvindar K Singh-BainsVanessa K MorrisAndrew N ClarksonMaurice A CurtisWickliffe C AbrahamStephanie M HughesRichard L M FaullAnthony J KettleMike DragunowMark B Hampton

Published in: Acta neuropathologica communications (2022)

Our report indicates that vascular changes may drive neutrophil adhesion and NETosis, and that neutrophil-derived MPO may lead to vascular oxidative stress and be a relevant therapeutic target in AD.

Keyphrases

oxidative stress
cognitive decline
ischemia reperfusion injury
multiple sclerosis
blood brain barrier
induced apoptosis
diabetic rats
mild cognitive impairment
cerebral ischemia
heat stress