Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease.
Leon C D SmythHelen C MurrayMadison HillEve van LeeuwenBlake HighetNicholas J MagonMahyar OsanlouySophie N MathiesenBruce MockettMalvindar K Singh-BainsVanessa K MorrisAndrew N ClarksonMaurice A CurtisWickliffe C AbrahamStephanie M HughesRichard L M FaullAnthony J KettleMike DragunowMark B HamptonPublished in: Acta neuropathologica communications (2022)
Our report indicates that vascular changes may drive neutrophil adhesion and NETosis, and that neutrophil-derived MPO may lead to vascular oxidative stress and be a relevant therapeutic target in AD.