Biomechanical engineering analysis of an acute papillary muscle rupture disease model using an innovative 3D-printed left heart simulator.

Mateo Marin-Cuartas Yuanjia ZhuAnnabel M Imbrie-MooreMatthew H ParkRobert J WilkersonMatthew LeipzigPearly K PandyaMichael J PaulsenMichael A BorgerY Joseph Woo

Published in: Interactive cardiovascular and thoracic surgery (2022)

The haemodynamic effects of acute PM rupture vary considerably according to the site and extent of the rupture. Rupture of ≤2/3 of chordae from 1 PM head or rupture at the posteromedial PM lead to less marked haemodynamics effects, suggesting a higher likelihood of tolerating surgery. Rupture at the anterolateral PM, specifically the anterior head, rupture of >2/3 of chordae from 1 PM head or regurgitation fraction >60% led to marked haemodynamic instability, suggesting the potential benefit from bridging strategies prior to surgery.

Keyphrases

particulate matter
air pollution
polycyclic aromatic hydrocarbons
heavy metals
minimally invasive
liver failure
mitral valve
water soluble
heart failure
skeletal muscle
respiratory failure
intensive care unit
aortic dissection
hepatitis b virus
risk assessment
percutaneous coronary intervention
clear cell