Imaging Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3 K27M Mutation.

Mariam S Aboian David A Solomon E Felton Marc C Mabray Javier E Villanueva-Meyer Romain Mueller Soonmee Cha

Published in: AJNR. American journal of neuroradiology (2017)

We describe, for the first time, the MR imaging features of pediatric diffuse midline gliomas with histone H3 K27M mutation. Similar to the heterogeneous histologic features among these tumors, they also have a diverse imaging appearance without distinguishing features from histone H3 wildtype diffuse gliomas.

Keyphrases

high grade
low grade
high resolution
dna methylation
gene expression
young adults
contrast enhanced