Plasma proteome profiling identifies changes associated to AD but not to FTD.
R Babapour MofradM Del CampoC F W PeetersL H H MeeterH SeelaarM Koel-SimmelinkI H G B RamakersH A M MiddelkoopP P De DeynJ A H R ClaassenJ C van SwietenC BridelJ J M HoozemansP ScheltensW M van der FlierY A L PijnenburgCharlotte E TeunissenPublished in: Acta neuropathologica communications (2022)
We identified a promising plasma protein panel as a minimally-invasive tool to aid in the differential diagnosis of FTD from AD, which was primarily associated to AD pathophysiology. The lack of plasma profiles specifically associated to FTD or its pathological subtypes might be explained by FTD heterogeneity, calling for FTD studies using large and well-characterize cohorts.