Cannabinoid receptor type 1 antagonist inhibits progression of obesity-associated nonalcoholic steatohepatitis in a mouse model by remodulating immune system disturbances.

Chin-Chang ChenZi-Yu ChangFuu-Jen TsaiShih-Yin Chen

Published in: Immunity, inflammation and disease (2020)

These findings suggested that a blockade caused by CB1 reduced obesity-associated NASH progression via correction of immune system dysregulations and elevated inflammatory responses in the liver tissues.

Keyphrases

insulin resistance
mouse model
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
gene expression
adipose tissue
skeletal muscle
physical activity