The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation.

Yaozong WeiBo PanJianpeng QinBeijia CaoTianyi LvJiangfeng YeAo NingKunlin DuXiangyi ChenShuqi ZouShengqin ZangGuozhi YuTianzeng SongQiuxia LiangGuang-Bin Zhou

Published in: Journal of animal science and biotechnology (2024)

Our findings revealed the mechanism of oxidative stress inducing repressed development of PA embryos from vitrified mouse MII oocytes and found a potent and easy-obtained short peptide that could significantly rescue the decreased developmental potential of vitrified oocytes, which would potentially contribute to reproductive medicine, animal protection, and breeding.

Keyphrases

oxidative stress
dna methylation
dna damage
gene expression
single cell
ischemia reperfusion injury
risk assessment
pregnant women
induced apoptosis
human health
endoplasmic reticulum stress
heat shock protein