Dupilumab efficacy in chronic rhinosinusitis with nasal polyps from SINUS-52 is unaffected by eosinophilic status.

Shigeharu FujiedaShoji MatsuneSachio TakenoNobuo OhtaMikiya AsakoClaus BachertTomoyuki InoueYoshinori TakahashiHiroyuki FujitaYamo DenizPaul RoweBenjamin OrtizYongtao LiLeda P Mannent

Published in: Allergy (2021)

Dupilumab produced consistent improvement in symptoms of severe CRSwNP irrespective of ECRS status. Therefore, blood eosinophil level may not be a suitable biomarker for dupilumab efficacy in CRSwNP.

Keyphrases

chronic rhinosinusitis

atopic dermatitis

early onset

depressive symptoms