Severe COVID-19 pneumonia: Perfusion analysis in correlation with pulmonary embolism and vessel enlargement using dual-energy CT data.
Florian PoschenriederStefanie MeilerMatthias LubnowFlorian ZemanJanine RennertGregor ScharfJan SchaibleChristian StroszczynskiMichael PfeiferOkka W HamerPublished in: PloS one (2021)
DECT revealed the opacifications in a subset of patients with severe COVID-19 pneumonia to be perfused non-uniformly with some being hypo- and others being hyperperfused. Mean iodine uptake in opacifications (both ground-glass and consolidation) was higher compared to normally aerated lung except for areas with upstream pulmonary embolism. Vessel enlargement correlated with iodine uptake: In summary, in a cohort of 27 consecutive patients with severe COVID-19 pneumonia, dual-energy CT demonstrated a wide range of iodine uptake in pulmonary ground-glass opacifications and consolidations as a surrogate marker for hypo- and hyperperfusion compared to normally aerated lung. Applying DECT to determine which pathophysiology is predominant might help to tailor therapy to the individual patient´s needs.
Keyphrases
- dual energy
- pulmonary embolism
- coronavirus disease
- computed tomography
- sars cov
- image quality
- inferior vena cava
- contrast enhanced
- early onset
- magnetic resonance imaging
- respiratory syndrome coronavirus
- pulmonary hypertension
- community acquired pneumonia
- respiratory failure
- magnetic resonance
- case report
- electronic health record
- single cell
- machine learning
- data analysis
- acute respiratory distress syndrome
- bone marrow
- deep learning
- mechanical ventilation