Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response After Ethanol Feeding in Mice.

Kyle Lauren PoulsenMegan R McMullenEmily HuangChristopher D KiblerMegan M SheehanLin LengRichard BucalaLaura E Nagy

Published in: Alcoholism, clinical and experimental research (2019)

The current study revealed that, in addition to its cytokine/chemokine functions, MIF is an upstream regulator of UPR in response to EtOH feeding in mice. Importantly, both MIF and UPR can either protect or contribute to liver injury, dependent upon the stage or severity of EtOH-induced liver injury.

Keyphrases

liver injury
drug induced
high fat diet induced
adipose tissue
endoplasmic reticulum stress
transcription factor
metabolic syndrome