Endothelial Cell Activation by SARS-CoV-2 Spike S1 Protein: A Crosstalk between Endothelium and Innate Immune Cells.
Bianca Maria RotoliAmelia BarilliRossana VisigalliFrancesca FerrariValeria Dall'AstaPublished in: Biomedicines (2021)
Our data suggest that pro-inflammatory mediators released by spike-activated macrophages amplify the activation of endothelial cells, likely contributing to the impairment of vascular integrity and to the development of a pro-coagulative endothelium.
Keyphrases
- endothelial cells
- innate immune
- sars cov
- nitric oxide
- induced apoptosis
- high glucose
- cell cycle arrest
- electronic health record
- vascular endothelial growth factor
- respiratory syndrome coronavirus
- big data
- signaling pathway
- anti inflammatory
- protein protein
- oxidative stress
- cell proliferation
- pi k akt
- amino acid
- data analysis