Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems.
Jessica E SalvatoreJeanne E SavagePeter B BarrAaron R WolenFazil AlievEero VuoksimaaAntti LatvalaLea PulkkinenRichard J RoseJaakko KaprioDanielle M DickPublished in: Alcoholism, clinical and experimental research (2017)
These findings highlight the potential utility of integrating functional genomic annotation information to increase the signal-to-noise ratio in polygenic scores and identify genetic variants that may be most susceptible to environmental modification.