Metabolomics for the design of new metabolic engineering strategies for improving aerobic succinic acid production in Escherichia coli.

Antonio ValleZamira SotoHowbeer MuhamadaliKatherine A HollywoodYun XuJonathan R LloydRoyston GoodacreDomingo CanteroGema CabreraJorge Bolivar

Published in: Metabolomics : Official journal of the Metabolomic Society (2022)

Metabolomics can serve as a holistic tool to identify bottlenecks in metabolic pathways by a non-rational design. Genetic manipulation to release these restrictions could increase the production of succinate.

Keyphrases

escherichia coli
mass spectrometry
genome wide
high intensity
gene expression
copy number
dna methylation
pseudomonas aeruginosa
multidrug resistant