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The Dfam community resource of transposable element families, sequence models, and genome annotations.

Jessica StorerRobert M HubleyJeb RosenTravis J WheelerArian F Smit
Published in: Mobile DNA (2021)
Dfam is an open access database of repetitive DNA families, sequence models, and genome annotations. The 3.0-3.3 releases of Dfam ( https://dfam.org ) represent an evolution from a proof-of-principle collection of transposable element families in model organisms into a community resource for a broad range of species, and for both curated and uncurated datasets. In addition, releases since Dfam 3.0 provide auxiliary consensus sequence models, transposable element protein alignments, and a formalized classification system to support the growing diversity of organisms represented in the resource. The latest release includes 266,740 new de novo generated transposable element families from 336 species contributed by the EBI. This expansion demonstrates the utility of many of Dfam's new features and provides insight into the long term challenges ahead for improving de novo generated transposable element datasets.
Keyphrases
  • healthcare
  • mental health
  • rna seq
  • genome wide
  • high frequency
  • gram negative
  • dna methylation
  • circulating tumor
  • emergency department
  • cell free
  • clinical practice
  • single cell
  • multidrug resistant
  • adverse drug