Impact of maternal iron deficiency on the auditory functions in the young and adult guinea pig.
Nora SheroSylvain FisetBrian BlakleyJean-Luc JougleuxMarc E SuretteMohamed ThabetFrance M RiouxPublished in: Nutritional neuroscience (2017)
No significant difference between dietary groups was measured in hearing threshold and absolute latencies in pups at PNd24 and PNd84. Although the ID offspring (n = 16) did not differ in brainstem transmission times (BTTs) at 80 dB compare to the IS siblings (n = 25) at PNd24, they showed significant delayed inter-peak latency (IPL) I-IV at 100 dB suggesting a delayed BTT. At PNd84, the latency of all peaks including IPL I-IV at 80 and 100 dB significantly decreased and was also similar in pups from both dietary groups suggesting a better brain maturation. This is the first study investigating the long-term impact of maternal iron deficiency on the auditory functions in the guinea pig offspring during early development to adulthood.
Keyphrases
- iron deficiency
- hearing loss
- high fat diet
- birth weight
- working memory
- pregnancy outcomes
- depressive symptoms
- white matter
- intellectual disability
- type diabetes
- resting state
- metabolic syndrome
- weight gain
- body mass index
- pregnant women
- functional connectivity
- young adults
- blood brain barrier
- autism spectrum disorder