Three residues in the BTB domain promote a good partnership between NuRD and Thpok.
Kazuki OkuyamaIchiro TaniuchiPublished in: Science immunology (2022)
Among the BTB-ZF transcription factor family, three amino acids in the BTB domain make Thpok unique in repressing cytotoxic lineage-related genes via recruitment of the NuRD chormatin-remodeling complex (see the related Research Article by Gao et al. ).