Comparative analysis of creatinine and osmolality as urine normalization strategies in targeted metabolomics for the differential diagnosis of asthma and COPD.
Mona M KhamisTeagan HoltHanan AwadAnas El-AneedDarryl J AdamkoPublished in: Metabolomics : Official journal of the Metabolomic Society (2018)
Our findings suggest that targeted urine metabolomic data can be normalized for hydration using creatinine or osmolality with no significant impact on the diagnostic accuracy of the model.