Three-Component cine , ipso -Disubstitution of Nitrocoumarins.
Vincent VedovatoAnghelo Josh GanganoIon GhivirigaAlexander J GrenningPublished in: Organic letters (2024)
The development of a three-component cine , ipso -disubstitution of nitrocoumarins is reported. The reaction leverages the electrophilicity of nitrocoumarins, the nucleophilicity of nitronates, and the leaving group ability of nitrite (NO 2 - ) to yield complex polyfunctionalized biaryls that often display stable axial chirality.
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