LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin.

Junyi YuWei WangJining YangYe ZhangXue GongHao LuoNian CaoZaicheng XuMiao TianPeili YangQiao MeiZhi ChenZhuxin LiChuanwei LiXudong DuanQing Rex LyuChen GaoBing Zhang Yibin Wang Gengze Wu Chunyu Zeng

Published in: Circulation research (2022)

PSR is a VSMC-enriched gene, and its transcript IncPSR and encoded protein (arteridin) coordinately regulate transcriptional reprogramming through a shared interacting partner, YBX1. This is a previously uncharacterized regulatory circuit in VSMC phenotype switching during vascular remodeling, with lncPSR/arteridin as potential therapeutic targets for the treatment of VSMC phenotype switching-related vascular remodeling.

Keyphrases

transcription factor
protein protein
gene expression
amino acid
long non coding rna
binding protein
genome wide
copy number
dna methylation
small molecule
risk assessment
protein kinase
combination therapy
climate change
long noncoding rna