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Single-Cell CD4 and CD8 T-Cell Secretome Profiling Reveals Temporal and Niche Differences in Acute Myeloid Leukemia Following Immune Checkpoint Blockade Therapy.

Jessica L RootPoonam N DesaiChristopher LyBofei WangFatima Zahra JelloulJing ZhouSean MackayMansour AlfayezJairo MatthewsSherry PiercePatrick K RevilleNaval G DaverHussein A Abbas
Published in: Cancer research communications (2024)
We found T-cell polyfunctionality differs between local and systemic microenvironments. Enhanced variability in proteomic profiles of bone marrow CD4 T cells post-IO suggests their pivotal role in AML treatment response. Single-cell analysis identified novel CD4 and CD8 T-cell functional groups linked to immunotherapy response within the bone marrow.
Keyphrases
  • single cell
  • bone marrow
  • rna seq
  • mesenchymal stem cells
  • high throughput
  • acute myeloid leukemia
  • nk cells
  • label free