Fenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease.

Chao TangXiaoqing DengJingru QuYahui MiaoLei TianMan ZhangXiaoyu LiBei SunLiming Chen

Published in: Drug design, development and therapy (2023)

Fenofibrate improves lipid accumulation and apoptosis through the AMPK/FOXA2/MCAD pathway. MCAD may be a potential therapeutic target of DKD, and the use of fenofibrate as a treatment for DKD warrants further study.

Keyphrases

oxidative stress
type diabetes
cell proliferation
endoplasmic reticulum stress
cell death
cell cycle arrest
skeletal muscle
wound healing
signaling pathway