Procedure for infusion of autologous mitochondria through the carotid artery in porcine brain.
Miguel A OrregoSamuel H S LevyCory M KellyGianfranco ArroyoLuz M ToribioHéctor H GarcíaIsaac Josh AbecassisPublished in: Revista peruana de medicina experimental y salud publica (2021)
Mitochondria are complex organelles that play a critical role within the cell; mitochondrial dysfunction can result in significant cell damage or death. Previous studies have demonstrated the promising therapeutic effects of autologous mitochondria transplantation into ischemic cardiac tissue; however, few studies have examined the in vivo effects of mitochondria infusion into the brain. The aim of this study is to report a procedure for carotid infusion of autologous mitochondria into porcine brains. By using this infusion technique, we propose that a selective and minimally invasive administration is feasible and may provide benefits in the treatment of various central nervous system disorders.
Keyphrases
- cell therapy
- minimally invasive
- cell death
- endoplasmic reticulum
- reactive oxygen species
- low dose
- bone marrow
- single cell
- white matter
- resting state
- platelet rich plasma
- cerebral ischemia
- oxidative stress
- mesenchymal stem cells
- left ventricular
- multiple sclerosis
- case control
- functional connectivity
- robot assisted
- ischemia reperfusion injury
- blood brain barrier