Clinical Outcome of Leiomyosarcomas With Somatic Alteration in Homologous Recombination Pathway Genes.

Evan Rosenbaum Philip JonssonKenneth SeierLi-Xuan QinPing ChiMark DicksonMrinal GounderCiara KellyMary L KeohanBenjamin A NacevMark T A DonoghueSarah ChiangSamuel SingerMarc Ladanyi Cristina R AntonescuMartee L HensleySujana MovvaSandra P D'AngeloWilliam D Tap

Published in: JCO precision oncology (2020)

Patients with LMS with homologous recombination pathway gene alterations have poor clinical outcomes, particularly those with non-BRCA gene alterations. HRD score calculated from a targeted exome panel did not discern disparate clinical outcomes.

Keyphrases

dna repair
copy number
dna damage
genome wide
genome wide identification
genome wide analysis
oxidative stress
cancer therapy
transcription factor
gene expression
drug delivery