Significance of p53 and presence of differentiated vulvar intra-epithelial neoplasia (dVIN) at resection margin in early stage human papillomavirus-independent vulvar squamous cell carcinoma.
Emily F ThompsonKathryn ShumRichard W C WongGiorgia TrevisanJanine SenzJutta HuvilaSamuel LeungDavid G HuntsmanC Blake GilksJessica N McAlpineLynn HoangAmy JamiesonPublished in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2022)
Patients with stage I-II HPV-I vulvar squamous cell carcinoma with margins positive for either dVIN or p53abn immunohistochemistry without morphologic dVIN showed increased disease recurrence, regardless of invasive margin distance. These findings show that p53 immunohistochemistry is a useful adjunct for evaluating margin status in HPV-I vulvar squamous cell carcinoma and may support repeat excision for positive in situ margins (dVIN or p53abn immunohistochemistry).