5- exo -Selective asymmetric bromolactonization of stilbenecarboxylic acids catalyzed by phenol-bearing chiral thiourea.

Masayuki SuganoTsubasa InokumaYousuke YamaokaKen-Ichi Yamada

Published in: Organic & biomolecular chemistry (2023)

We developed a novel thiourea Lewis-base catalyst with phenol moieties for the enantioselective 5- exo -bromolactonization of stilbenecarboxylic acids to afford chiral 3-substituted phthalides. The phenol moieties are crucial for the enantio- and regio-selectivity.

Keyphrases

ionic liquid
room temperature
capillary electrophoresis
molecular docking
reduced graphene oxide
mass spectrometry
molecular dynamics simulations
structural basis