c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming.
Qiang ZhangKaisa CuiXiaoya YangQilang HeJing YuLi YangGang YaoWeiwei GuoZhanhao LuoYugeng LiuYuan ChenZhen HePing LanPublished in: Clinical and translational medicine (2023)
Our study highlights the essential roles of metabolic rate-limiting enzymes in tumourigenesis and their crosstalk with Myc, and the Myc-IMPDH1/2 axis promotes tumourigenesis by altering GTP metabolic reprogramming. Our results propose the inhibition of IMPDH1 as a viable option for cancer treatment.
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