Nanocomposites-based targeted oral drug delivery systems with infliximab in a murine colitis model.

Jung Min KimDa Hye KimHyo Jeong ParkHyun Woo MaI Seul ParkMijeong SonSo Youn RoSeokmann HongHyo Kyung HanSoo Jeong LimSeung Won KimJung Min Kim

Published in: Journal of nanobiotechnology (2020)

We present orally administered antibody delivery systems which improved efficacy in murine colitis while reducing systemic exposure. These oral delivery systems suggest a promising therapeutic approach for treating IBD.

Keyphrases

ulcerative colitis
cancer therapy
reduced graphene oxide
gold nanoparticles
carbon nanotubes
patients with inflammatory bowel disease