DNA methylation analysis of tumor suppressor genes in liquid biopsy components of early stage NSCLC: a promising tool for early detection.

Athina N MarkouD LondraV TserpeliΙ KolliasE TsarouchaI VamvakarisK PotarisI PaterasΑ KotsakisV GeorgouliasΕ Lianidou

Published in: Clinical epigenetics (2022)

DNA methylation of these five gene promoters was significantly lower in CTCs and plasma-cfDNA than in the primary tumors. Combination of DNA methylation analysis in CTC and plasma-cfDNA was associated with worse DFI of NSCLC patients. Additional studies are required to validate our findings in a large cohort of early stage NSCLC patients.

Keyphrases

dna methylation
early stage
genome wide
end stage renal disease
small cell lung cancer
newly diagnosed
chronic kidney disease
gene expression
advanced non small cell lung cancer
squamous cell carcinoma
transcription factor
ionic liquid
lymph node
fine needle aspiration
rectal cancer
bioinformatics analysis