A proteomic analysis of atrial fibrillation in a prospective longitudinal cohort (AGES-Reykjavik study).
Thorarinn JonmundssonAnna E SteindorsdottirThomas R AustinElisabet A FrickGisli Thor AxelssonLenore J LaunerBruce M PsatyJoseph J LoureiroAnthony P OrthThor AspelundValur EmilssonJames S FloydLori L JenningsVilmundur GudnasonValborg GudmundsdottirPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
The AF proteomic signature includes biologically relevant proteins, some of which may be causal. It mainly reflects an NT-proBNP-dependent consequence of the genetic liability to AF. NT-proBNP is a promising marker for incident AF in the short term, but risk assessment incorporating a PRS may improve long-term risk assessment.