The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells.
Catherine H KaschulaRosanna TuveriEllen NgarandeKevin DzoboChristopher BarnettDaniel A KuszaLisa M GrahamArieh A KatzMohamed Suhail RafudeenM Iqbal ParkerRoger HunterGeorgia SchäferPublished in: BMC cancer (2019)
The garlic-derived phytochemical ajoene targets and covalently modifies vimentin in cancer cells by S-thiolating Cys-328. This interaction results in the disruption of the vimentin filament network and contributes to the anti-metastatic activity of ajoene in cancer cells.