Deep serological profiling of the Trypanosoma cruzi TSSA antigen reveals different epitopes and modes of recognition by Chagas disease patients.

Guadalupe RomerLeonel A BraccoAlejandro D RicciVirginia BalouzLuisa BernáJuan C VillarJanine M RamseyMelissa S NolanFaustino TorricoNorival KesperJaime AltchehCarlos RobelloCarlos A BuscagliaFernán Agüero

Published in: PLoS neglected tropical diseases (2023)

Overall, our findings shed new light into TSSA evolution, epitope landscape and modes of recognition by Chagas disease patients; and have practical implications for the design and/or evaluation of T. cruzi serotyping strategies.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
single cell
patient reported outcomes
monoclonal antibody