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Deep serological profiling of the Trypanosoma cruzi TSSA antigen reveals different epitopes and modes of recognition by Chagas disease patients.

Guadalupe RomerLeonel A BraccoAlejandro D RicciVirginia BalouzLuisa BernáJuan C VillarJanine M RamseyMelissa S NolanFaustino TorricoNorival KesperJaime AltchehCarlos RobelloCarlos A BuscagliaFernán Agüero
Published in: PLoS neglected tropical diseases (2023)
Overall, our findings shed new light into TSSA evolution, epitope landscape and modes of recognition by Chagas disease patients; and have practical implications for the design and/or evaluation of T. cruzi serotyping strategies.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • chronic kidney disease
  • newly diagnosed
  • prognostic factors
  • peritoneal dialysis
  • single cell
  • patient reported outcomes
  • monoclonal antibody