Sequential screening for lung cancer in a high-risk group: randomised controlled trial: LungSEARCH: a randomised controlled trial of Surveillance using sputum and imaging for the EARly detection of lung Cancer in a High-risk group.
Stephen G SpiroPallav L ShahRobert C RintoulJeremy GeorgeSamuel M JanesMatthew CallisterMarco NovelliPenny ShawGabrijela KocjanChris GriffithsMary FalzonRichard BootonNicholas MageeMichael PeakePaul DhillonKishore SridharanAndrew G NicholsonSimon PadleyMagali N TaylorAsia AhmedJack AllenYenting NgaiNyasha ChinyanganyaVictoria Ashford-TurnerSarah LewisDahmane OukrifPamela RabbittsNicholas CounsellAllan HackshawPublished in: The European respiratory journal (2019)
Our sequential strategy, using sputum cytology/cytometry to select high-risk individuals for AFB and LDCT, did not lead to a clear stage shift and did not improve the efficiency of lung cancer screening.