Outcome-Related Signatures Identified by Whole Transcriptome Sequencing of Resectable Stage III/IV Melanoma Evaluated after Starting Hu14.18-IL2.

Richard K YangIgor B KuznetsovErik A RanheimJun S WeiSivasish SindiriBerkley E GryderVineela GangalapudiYoung K SongViharkumar Patel Jacquelyn A HankCindy ZulegerAmy K ErbeZachary S MorrisRenae QualeKyungMann Kim Mark R AlbertiniJaved KhanPaul M Sondel

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

We interpret these data to signify that both immunologic and tumoral cell processes, as measured by RNA-sequencing analyses detected shortly after initiation of hu14.18-IL2 therapy, are associated with long-term survival and could potentially be used as prognostic biomarkers in tumor resection specimens obtained after initiating neoadjuvant immunotherapy.

Keyphrases

single cell
rna seq
locally advanced
rectal cancer
genome wide
electronic health record
squamous cell carcinoma
gene expression
big data
radiation therapy
machine learning
stem cells
drug induced