Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism.

Peng-Fei TangXiang ZhengXiao-Xia Hu Cheng-Cheng Yang Zhe ChenJian-Chang QianJian-Ping CaiGuo-Xin Hu

Published in: Drug design, development and therapy (2020)

These findings were the first evaluation of all these infrequent CYP2C9 and CYP3A4 alleles for sildenafil metabolism; when treating people who carry these CYP2C9 and CYP3A4 variants, there should be more focus on the relation of dose intensity, side effects and therapeutic efficacy when administering sildenafil. The study will provide fundamental data on effect of CYP2C9 and CYP3A4 allelic variation on sildenafil metabolism for further clinical research.

Keyphrases

pulmonary hypertension
pulmonary arterial hypertension
big data
gene expression
dna methylation