Trans-ethnic Polygenic Risk Scores for Body Mass Index: An International Hundred K+ Cohorts Consortium Study.

Hui-Qi QuJohn J ConnollyPeter KraftJirong LongAlexandre PereiraChristopher FlatleyConstance TurmanBram PrinsFrank MentchPaulo A LotufoPer MagnusMeir J StampferRulla TamimiA Heather EliassenWei ZhengGun Peggy Stromstad KnudsenOyvind HelgelandAdam S Butterworth Hakon H HakonarsonPatrick M Sleiman

Published in: medRxiv : the preprint server for health sciences (2023)

Widespread use of PRS in the clinic is hampered by a lack of genotyping data in individuals of non-European ancestry for the vast majority of traits. Here we show that for a truly polygenic trait such as BMI adjusting the summary statistics of a well powered European ancestry study using trans-ethnic LD reference results in a score that is predictive across a range of ancestries including East Asians and three-way admixed Brazilians.

Keyphrases

body mass index
genome wide
weight gain
primary care
electronic health record
physical activity
high throughput
genome wide association study
big data
weight loss