Scleroderma-specific autoantibodies embedded in immune complexes mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis.
Elena RaschiDaniela PriviteraCaterina BodioPaola Adele LonatiMaria Orietta BorghiFrancesca IngegnoliPier Luigi MeroniCecilia Beatrice ChighizolaPublished in: Arthritis research & therapy (2020)
These data provide the first demonstration of the pathogenicity of ICs from scleroderma patients with different autoantibodies on the endothelium. Endothelial activation induced by SSc-ICs ultimately led to a pro-fibrotic phenotype in healthy skin fibroblasts.
Keyphrases
- systemic sclerosis
- interstitial lung disease
- systemic lupus erythematosus
- endothelial cells
- nitric oxide
- electronic health record
- oxidative stress
- big data
- anti inflammatory
- wound healing
- biofilm formation
- escherichia coli
- machine learning
- rheumatoid arthritis
- pseudomonas aeruginosa
- staphylococcus aureus
- data analysis
- artificial intelligence