Monochorionic twins discordant for trisomy 13: A case report, systematic literature search and synthesis of available evidence.

Emily F CornishRuwan WimalasunderaGeorge Attilakos

Published in: Clinical case reports (2020)

This article presents the tenth reported case of monochorionic twins discordant for trisomy 13. Discordant aneuploidies in monochorionic twins are rare. Aetiologies include mitotic error in early cell division and "rescue" chromosome loss in an initially trisomic zygote. Clinicians should offer early amniocentesis of both sacs and consider selective termination.

Keyphrases

gestational age
systematic review
single cell
palliative care
cell therapy
cell cycle
copy number
preterm birth
cell proliferation
bone marrow