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Association between the rs7583431 single nucleotide polymorphism close to the activating transcription factor 2 gene and the analgesic effect of fentanyl in the cold pain test.

Yoshinori AokiDaisuke NishizawaKaori YoshidaJunko HasegawaShinya KasaiKaori TakahashiYoshihiko KoukitaTatsuya IchinoheMasakazu HayashidaKen-Ichi FukudaAnd Kazutaka Ikeda
Published in: Neuropsychopharmacology reports (2018)
The present findings may contribute to adequate pain relief in individual patients. Although more research on the genetic factors that influence opioid sensitivity is needed, analgesic requirements may be predicted by analyzing ATF2SNPs, together with other polymorphisms of genes that are reportedly associated with opioid sensitivity, such as CREB1, OPRM1, and GIRK2.
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