Association between the rs7583431 single nucleotide polymorphism close to the activating transcription factor 2 gene and the analgesic effect of fentanyl in the cold pain test.
Yoshinori AokiDaisuke NishizawaKaori YoshidaJunko HasegawaShinya KasaiKaori TakahashiYoshihiko KoukitaTatsuya IchinoheMasakazu HayashidaKen-Ichi FukudaAnd Kazutaka IkedaPublished in: Neuropsychopharmacology reports (2018)
The present findings may contribute to adequate pain relief in individual patients. Although more research on the genetic factors that influence opioid sensitivity is needed, analgesic requirements may be predicted by analyzing ATF2SNPs, together with other polymorphisms of genes that are reportedly associated with opioid sensitivity, such as CREB1, OPRM1, and GIRK2.
Keyphrases
- chronic pain
- pain management
- genome wide
- neuropathic pain
- transcription factor
- end stage renal disease
- genome wide identification
- ejection fraction
- newly diagnosed
- copy number
- dna methylation
- signaling pathway
- anti inflammatory
- spinal cord injury
- prognostic factors
- spinal cord
- peritoneal dialysis
- dna binding
- patient reported outcomes
- patient reported
- postoperative pain