High Stability of a Donor-Acceptor Type Oxazepine-Containing Fluorophore and Its Applications in Cellular Imaging and Two-Photon Deep Tissue Imaging.

Heejo MoonYuna JungYoungseo KimByeong Wook KimJin Gyu ChoiNa Hee KimMyung Sook OhSungnam Park Byeong Moon Kim Dokyoung Kim

Published in: Organic letters (2019)

A new donor (D)-acceptor (A) type naphthalene-based oxazepine-containing fluorophore, OXN-1, is reported, which shows unusually high stability in various environments. Its photophysical properties and structural stabilities under harsh conditions are thoroughly examined. The high stability of OXN-1 is explained by quantum chemical calculations. Its exceptional bioimaging capabilities for cells with low cytotoxicity are verified. In addition, its deep tissue imaging ability with two-photon microscopy (TPM) is evaluated.

Keyphrases

high resolution
fluorescent probe
living cells
molecular dynamics
induced apoptosis
monte carlo
mass spectrometry
quantum dots
optical coherence tomography
cell cycle arrest
fluorescence imaging
photodynamic therapy
electron microscopy