Anatase-type one-dimensional TiO₂ nanowire was prepared by hydrothermal method. The nanowires were modified by three kinds of silane coupling agents, such as KH550, KH560 and KH570. Flocculation was caused when the amount of modifier reached a certain level. When KH570 was used at 3.0 percent, at 80 °C, 4 h, and pH value between 9 and 10, modified nanowires had the highest 56.5 percent lipophilization degree, the lowest 0.562 per/nm² surface hydroxyl number, and the maximal 121.2° static contact angle.