Synthesis of diversely substituted bis-pyrrolizidino/ thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via sequential azomethine ylide cycloaddition.

Meenakshi SinghAbhijit Hazra Yogesh P BharitkarRitu KaliaAshutosh SahooSneha SahaV RavichandiranShekhar GhoshNirup B Mondal

Published in: RSC advances (2018)

Curcumin has been transformed to several diversely substituted bis-pyrrolizidino/thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via a sequential azomethine ylide cycloaddition reaction using isatins/acenaphthoquinone and proline/thioproline as the reagents. The products were separated via extensive chromatography and characterized by 1D/2D NMR and HRMS analysis.

Keyphrases

molecular docking
ionic liquid
mass spectrometry
magnetic resonance
high resolution
high speed
liquid chromatography
tandem mass spectrometry
high resolution mass spectrometry
solid state