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Gene of the month: VSTM2A .

Lisha WangOsman YilmazBrendan A VeenemanYuping ZhangSaravana M DhanasekaranRohit Mehra
Published in: Journal of clinical pathology (2024)
The V-set and transmembrane domain containing 2A ( VSTM2A) gene is located on chromosome 7. In the physiological state, VSTM2A regulates preadipocyte cell differentiation. VSTM2A is highly expressed in normal human brain tissue and minimally expressed in other normal tissues. Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a distinct renal tumour subtype with signature chromosomal copy number alterations and an indolent outcome in the majority of cases. VSTM2A overexpression is highly enriched in this renal cancer subtype and has been shown to have potential diagnostic value in distinguishing MTSCC from renal tumours with overlapping histological appearances.
Keyphrases
  • copy number
  • mitochondrial dna
  • genome wide
  • dna methylation
  • gene expression
  • papillary thyroid
  • cell proliferation
  • squamous cell carcinoma
  • risk assessment