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IL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophils.

Melanie KienzlCarina HasenoehrlPaulina Valadez-CosmesKathrin MaitzArailym SarsembayevaEva SturmAkos HeinemannJulia KarglRudolf Schicho
Published in: Oncoimmunology (2020)
AOM: azoxymethane; bmRPMI: bone marrow RPMI; CRC: colorectal cancer; CFSE: carboxyfluorescein succinimidyl ester; DSS: dextran sulfate sodium; EPX: eosinophil peroxidase; INF-γ: interferon gamma; ILC: innate lymphoid cell; IL-33: interleukin-33; IL-5: interleukin-5; MDSC: myeloid derived suppressor cells; NK cells: natural killer cells; P/S: penicillin/streptomycin; rm: recombinant mouse; T regs: regulatory T cells; TATE: tumor associated tissue eosinophilia; TNF-α: tumor necrosis factor alpha.
Keyphrases
  • regulatory t cells
  • nk cells
  • bone marrow
  • natural killer cells
  • dendritic cells
  • rheumatoid arthritis
  • induced apoptosis
  • mesenchymal stem cells
  • single cell
  • cell cycle arrest
  • nitric oxide
  • cell death
  • signaling pathway