Effects of Vitamin D Deficiency on Proliferation and Autophagy of Ovarian and Liver Tissues in a Rat Model of Polycystic Ovary Syndrome.

Krisztina LajtaiCsilla Terézia NagyRóbert TarszabóRita BenkőLeila HadjadjRéka Eszter SzivaDóra GersziBálint BányaiPéter FerdinandyGyörgy László NádasyZoltán GiriczEszter Mária HorváthSzabolcs Várbíró

Published in: Biomolecules (2019)

Vitamin D deficiency itself might lead to disrupted ovarian maturation and autophagy malfunction in the liver. Preventing Akt phosphorylation may contribute to the beneficial effect of vitamin D treatment on ovarian function in hyperandrogenism.

Keyphrases

polycystic ovary syndrome
signaling pathway
insulin resistance
cell death
endoplasmic reticulum stress
oxidative stress
gene expression
cell proliferation
adipose tissue
protein kinase
smoking cessation