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Serum protein binding of 25 antiepileptic drugs in a routine clinical setting: A comparison of free non-protein-bound concentrations.

Philip N PatsalosMiguel ZugmanCharlotte LakeAnthony JamesNeville RatnarajJosemir W Sander
Published in: Epilepsia (2017)
These data provide a comprehensive comparison of serum protein binding of all available AEDs including the metabolites, carbamazepine-epoxide and N-desmethyl-clobazam. Knowledge of the free fraction of these AEDs can be used to optimize epilepsy treatment.
Keyphrases
  • binding protein
  • protein protein
  • amino acid
  • healthcare
  • electronic health record
  • machine learning
  • dna binding
  • small molecule
  • clinical practice
  • transcription factor
  • replacement therapy
  • data analysis